The LRRK2 N-terminal domain influences vesicle trafficking: impact of the E193K variant

The LRRK2 protein consists of multiple functional domains, including protein-binding domains at its N and C-terminus. Mutations in the Leucine-rich repeat kinase 2 gene (LRRK2) have been linked to familial and sporadic Parkinson’s disease (PD). We have recently described a novel variant falling with...

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Vydáno v:Sci Rep
Hlavní autoři: Marku, Algerta, Carrion, Maria Dolores Perez, Pischedda, Francesca, Marte, Antonella, Casiraghi, Zeila, Marciani, Paola, von Zweydorf, Felix, Gloeckner, Christian Johannes, Onofri, Franco, Perego, Carla, Piccoli, Giovanni
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2020
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7052203/
https://ncbi.nlm.nih.gov/pubmed/32123243
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60834-5
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