The LRRK2 G2385R variant is a partial loss-of-function mutation that affects synaptic vesicle trafficking through altered protein interactions

Mutations in the Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial Parkinson’s disease (PD). LRRK2 protein contains several functional domains, including protein-protein interaction domains at its N- and C-termini. In this study, we analyzed the functional features attributed to...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Carrion, Maria Dolores Perez, Marsicano, Silvia, Daniele, Federica, Marte, Antonella, Pischedda, Francesca, Di Cairano, Eliana, Piovesana, Ester, von Zweydorf, Felix, Kremmer, Elisabeth, Gloeckner, Christian Johannes, Onofri, Franco, Perego, Carla, Piccoli, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2017
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5511190/
https://ncbi.nlm.nih.gov/pubmed/28710481
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-017-05760-9
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