LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

Mutations in Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple domains executing several functions, including GTP hydrolysis, kinase activity, and protein binding. Robust evidence su...

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Detalhes bibliográficos
Main Authors: Cirnaru, Maria D., Marte, Antonella, Belluzzi, Elisa, Russo, Isabella, Gabrielli, Martina, Longo, Francesco, Arcuri, Ludovico, Murru, Luca, Bubacco, Luigi, Matteoli, Michela, Fedele, Ernesto, Sala, Carlo, Passafaro, Maria, Morari, Michele, Greggio, Elisa, Onofri, Franco, Piccoli, Giovanni
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2014
Assuntos:
Neuroscience
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034499/
https://ncbi.nlm.nih.gov/pubmed/24904275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00049
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