LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex

Mutations in Leucine-rich repeat kinase 2 gene (LRRK2) are associated with familial and sporadic Parkinson's disease (PD). LRRK2 is a complex protein that consists of multiple domains executing several functions, including GTP hydrolysis, kinase activity, and protein binding. Robust evidence su...

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Autori principali: Cirnaru, Maria D., Marte, Antonella, Belluzzi, Elisa, Russo, Isabella, Gabrielli, Martina, Longo, Francesco, Arcuri, Ludovico, Murru, Luca, Bubacco, Luigi, Matteoli, Michela, Fedele, Ernesto, Sala, Carlo, Passafaro, Maria, Morari, Michele, Greggio, Elisa, Onofri, Franco, Piccoli, Giovanni
Natura: Artigo
Lingua:Inglês
Pubblicazione: Frontiers Media S.A. 2014
Soggetti:
Neuroscience
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC4034499/
https://ncbi.nlm.nih.gov/pubmed/24904275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnmol.2014.00049
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