LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate

BACKGROUND: Lrrk2, a gene linked to Parkinson’s disease, encodes a large scaffolding protein with kinase and GTPase activities implicated in vesicle and cytoskeletal-related processes. At the presynaptic site, LRRK2 associates with synaptic vesicles through interaction with a panel of presynaptic pr...

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Publicat a:Mol Neurodegener
Autors principals: Belluzzi, Elisa, Gonnelli, Adriano, Cirnaru, Maria-Daniela, Marte, Antonella, Plotegher, Nicoletta, Russo, Isabella, Civiero, Laura, Cogo, Susanna, Carrion, Maria Perèz, Franchin, Cinzia, Arrigoni, Giorgio, Beltramini, Mariano, Bubacco, Luigi, Onofri, Franco, Piccoli, Giovanni, Greggio, Elisa
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2016
Matèries:
Research Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC4711005/
https://ncbi.nlm.nih.gov/pubmed/26758690
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13024-015-0066-z
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