Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy

Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to in...

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Vydáno v:Cell Mol Immunol
Hlavní autoři: Cai, Dongli, Li, Jiaming, Liu, Dingfeng, Hong, Shanjuan, Qiao, Qin, Sun, Qinli, Li, Pingping, Lyu, Nanan, Sun, Tiantian, Xie, Shan, Guo, Li, Ni, Ling, Jin, Liping, Dong, Chen
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051965/
https://ncbi.nlm.nih.gov/pubmed/31611650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0305-2
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