Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy

Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to in...

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Bibliographic Details
Published in:Cell Mol Immunol
Main Authors: Cai, Dongli, Li, Jiaming, Liu, Dingfeng, Hong, Shanjuan, Qiao, Qin, Sun, Qinli, Li, Pingping, Lyu, Nanan, Sun, Tiantian, Xie, Shan, Guo, Li, Ni, Ling, Jin, Liping, Dong, Chen
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051965/
https://ncbi.nlm.nih.gov/pubmed/31611650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0305-2
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