Tumor-expressed B7-H3 mediates the inhibition of antitumor T-cell functions in ovarian cancer insensitive to PD-1 blockade therapy

Although PD-L1/PD-1 blockade therapy has been approved to treat many types of cancers, the majority of patients with solid tumors do not respond well, but the underlying reason remains unclear. Here, we studied ovarian cancer (OvCa), a tumor type generally resistant to current immunotherapies, to in...

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Détails bibliographiques
Publié dans:Cell Mol Immunol
Auteurs principaux: Cai, Dongli, Li, Jiaming, Liu, Dingfeng, Hong, Shanjuan, Qiao, Qin, Sun, Qinli, Li, Pingping, Lyu, Nanan, Sun, Tiantian, Xie, Shan, Guo, Li, Ni, Ling, Jin, Liping, Dong, Chen
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group UK 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051965/
https://ncbi.nlm.nih.gov/pubmed/31611650
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41423-019-0305-2
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