Enhanced protection conferred by mucosal BCG vaccination associates with presence of antigen-specific lung tissue-resident PD-1(+) KLRG1(−) CD4(+) T cells

BCG, the only vaccine licensed against tuberculosis, demonstrates variable efficacy in humans. Recent preclinical studies highlight the potential for mucosal BCG vaccination to improve protection. Lung tissue-resident memory T cells reside within the parenchyma, potentially playing an important role...

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Publicat a:Mucosal Immunol
Autors principals: Bull, N. C., Stylianou, E., Kaveh, D. A., Pinpathomrat, N., Pasricha, J., Harrington-Kandt, R., Garcia-Pelayo, M. C., Hogarth, P. J., McShane, H.
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group US 2018
Matèries:
Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051908/
https://ncbi.nlm.nih.gov/pubmed/30446726
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41385-018-0109-1
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