EP2 receptor blockade attenuates COX-2 upregulation during intestinal inflammation

High levels of PGE(2) have been implicated in the pathogenesis of intestinal inflammatory disorders such as necrotizing enterocolitis (NEC) and peritonitis. However, PGE(2) has a paradoxical effect: its low levels promote intestinal homeostasis, whereas high levels may contribute to pathology. These...

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Veröffentlicht in:Shock
Hauptverfasser: Golden, Jamie, Illingworth, Laura, Kavarian, Patil, Escobar, Oswaldo, Delaplain, Patrick, Isani, Mubina, Wang, Jin, Lim, Joanna, Bowling, Jordan, Bell, Brandon, Gayer, Christopher P., Grishin, Anatoly, Ford, Henri R.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2020
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051888/
https://ncbi.nlm.nih.gov/pubmed/31490357
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/SHK.0000000000001444
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