Characterization of a potent and highly unusual minimally-enhancing antibody directed against dengue virus

Dengue virus is a major pathogen and severe infections can lead to life threatening dengue hemorrhagic fever (DHF). Dengue exists as four serotypes and DHF is often associated with secondary heterologous infections. Antibody dependent enhancement (ADE) may drive higher virus loads in these secondary...

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Veröffentlicht in:Nat Immunol
Hauptverfasser: Renner, Max, Flanagan, Aleksandra, Dejnirattisai, Wanwisa, Puttikhunt, Chunya, Kasinrerk, Watchara, Supasa, Piyada, Wongwiwat, Wiyada, Chawansuntati, Kriangkrai, Duangchinda, Thaneeya, Cowper, Alison, Midgley, Claire M, Malasit, Prida, Huiskonen, Juha T., Mongkolsapaya, Juthathip, Screaton, Gavin R., Grimes, Jonathan M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2018
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7051845/
https://ncbi.nlm.nih.gov/pubmed/30323338
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41590-018-0227-7
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