Subcellular localization of Rap1 GTPase activator CalDAG-GEFI is orchestrated by interaction of its atypical C1 domain with membrane phosphoinositides

BACKGROUND: The small GTPase Rap1 and its guanine nucleotide exchange factor, CalDAG-GEFI (CDGI), are critical for platelet function and hemostatic plug formation. CDGI function is regulated by a calcium binding EF hand regulatory domain and an atypical C1 domain with unknown function. OBJECTIVE: He...

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Publicat a:J Thromb Haemost
Autors principals: Sarker, Muzaddid, Goliaei, Ardeshir, Golesi, Florence, Poggi, Marjorie, Cook, Aaron, Khan, Mohammad A. I., Temple, Brenda R., Stefanini, Lucia, Canault, Matthias, Bergmeier, Wolfgang, Campbell, Sharon L.
Format: Artigo
Idioma:Inglês
Publicat: 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050387/
https://ncbi.nlm.nih.gov/pubmed/31758832
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jth.14687
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