Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Loss of function of TREM2, a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer’s disease (AD). We therefore examined whether soluble TREM2 (sTREM2) concentrations in cerebrospinal fluid (CSF) were associated with reduced rates of cognitive decl...

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Vydáno v:Sci Transl Med
Hlavní autoři: Ewers, Michael, Franzmeier, Nicolai, Suárez-Calvet, Marc, Morenas-Rodriguez, Estrella, Caballero, Miguel Angel Araque, Kleinberger, Gernot, Piccio, Laura, Cruchaga, Carlos, Deming, Yuetiva, Dichgans, Martin, Trojanowski, John Q., Shaw, Leslie M., Weiner, Michael W., Haass, Christian
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050285/
https://ncbi.nlm.nih.gov/pubmed/31462511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav6221
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