Increased soluble TREM2 in cerebrospinal fluid is associated with reduced cognitive and clinical decline in Alzheimer’s disease

Loss of function of TREM2, a key receptor selectively expressed by microglia in the brain, contributes to the development of Alzheimer’s disease (AD). We therefore examined whether soluble TREM2 (sTREM2) concentrations in cerebrospinal fluid (CSF) were associated with reduced rates of cognitive decl...

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發表在:Sci Transl Med
Main Authors: Ewers, Michael, Franzmeier, Nicolai, Suárez-Calvet, Marc, Morenas-Rodriguez, Estrella, Caballero, Miguel Angel Araque, Kleinberger, Gernot, Piccio, Laura, Cruchaga, Carlos, Deming, Yuetiva, Dichgans, Martin, Trojanowski, John Q., Shaw, Leslie M., Weiner, Michael W., Haass, Christian
格式: Artigo
語言:Inglês
出版: 2019
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Article
在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC7050285/
https://ncbi.nlm.nih.gov/pubmed/31462511
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1126/scitranslmed.aav6221
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