Synthesis and biological evaluation of novel cYY analogues targeting Mycobacterium tuberculosis CYP121A1

The rise in multidrug resistant (MDR) cases of tuberculosis (TB) has led to the need for the development of TB drugs with different mechanisms of action. The genome sequence of Mycobacterium tuberculosis (Mtb) revealed twenty different genes coding for cytochrome P450s. CYP121A1 catalyzes a C—C cros...

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Publicado no:Bioorg Med Chem
Main Authors: Kishk, Safaa M., McLean, Kirsty J., Sood, Sakshi, Helal, Mohamed A., Gomaa, Mohamed S., Salama, Ismail, Mostafa, Samia M., de Carvalho, Luiz Pedro S., Munro, Andrew W., Simons, Claire
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier Science 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049898/
https://ncbi.nlm.nih.gov/pubmed/30837169
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bmc.2019.02.051
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