Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

[Image: see text] Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole and imidazole/triazole group. The imidazole and triazole series with the short −CH(2)– linker displayed promising antimycobacterial activity, with the imidazol...

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Publicado en:J Med Chem
Autores principales: Taban, Ismail M., Elshihawy, Hosam E. A. E., Torun, Beyza, Zucchini, Benedetta, Williamson, Clare J., Altuwairigi, Dania, Ngu, Adeline S. T., McLean, Kirsty J., Levy, Colin W., Sood, Sakshi, Marino, Leonardo B., Munro, Andrew W., de Carvalho, Luiz Pedro S., Simons, Claire
Formato: Artigo
Lenguaje:Inglês
Publicado: American Chemical Society 2017
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748275/
https://ncbi.nlm.nih.gov/pubmed/29185746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01562
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