Novel Aryl Substituted Pyrazoles as Small Molecule Inhibitors of Cytochrome P450 CYP121A1: Synthesis and Antimycobacterial Evaluation

[Image: see text] Three series of biarylpyrazole imidazole and triazoles are described, which vary in the linker between the biaryl pyrazole and imidazole/triazole group. The imidazole and triazole series with the short −CH(2)– linker displayed promising antimycobacterial activity, with the imidazol...

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Bibliografiset tiedot
Julkaisussa:J Med Chem
Päätekijät: Taban, Ismail M., Elshihawy, Hosam E. A. E., Torun, Beyza, Zucchini, Benedetta, Williamson, Clare J., Altuwairigi, Dania, Ngu, Adeline S. T., McLean, Kirsty J., Levy, Colin W., Sood, Sakshi, Marino, Leonardo B., Munro, Andrew W., de Carvalho, Luiz Pedro S., Simons, Claire
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: American Chemical Society 2017
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC5748275/
https://ncbi.nlm.nih.gov/pubmed/29185746
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acs.jmedchem.7b01562
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