Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

The pathogenesis of acute myeloid leukemia (AML) involves serial acquisition of mutations controlling several cellular processes, requiring combination therapies affecting key downstream survival nodes in order to treat the disease effectively. The BCL2 selective inhibitor venetoclax has potent anti...

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Detalhes bibliográficos
Publicado no:Haematologica
Main Authors: Han, Lina, Zhang, Qi, Dail, Monique, Shi, Ce, Cavazos, Antonio, Ruvolo, Vivian R., Zhao, Yang, Kim, Eugene, Rahmani, Mohamed, Mak, Duncan H., Jin, Sha S., Chen, Jun, Phillips, Darren C., Koller, Paul Bottecelli, Jacamo, Rodrigo, Burks, Jared K., DiNardo, Courtney, Daver, Naval, Jabbour, Elias, Wang, Jing, Kantarjian, Hagop M., Andreeff, Michael, Grant, Steven, Leverson, Joel D., Sampath, Deepak, Konopleva, Marina
Formato: Artigo
Idioma:Inglês
Publicado em: Ferrata Storti Foundation 2020
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Aticle
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049339/
https://ncbi.nlm.nih.gov/pubmed/31123034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.205534
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