Concomitant targeting of BCL2 with venetoclax and MAPK signaling with cobimetinib in acute myeloid leukemia models

The pathogenesis of acute myeloid leukemia (AML) involves serial acquisition of mutations controlling several cellular processes, requiring combination therapies affecting key downstream survival nodes in order to treat the disease effectively. The BCL2 selective inhibitor venetoclax has potent anti...

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Veröffentlicht in:Haematologica
Hauptverfasser: Han, Lina, Zhang, Qi, Dail, Monique, Shi, Ce, Cavazos, Antonio, Ruvolo, Vivian R., Zhao, Yang, Kim, Eugene, Rahmani, Mohamed, Mak, Duncan H., Jin, Sha S., Chen, Jun, Phillips, Darren C., Koller, Paul Bottecelli, Jacamo, Rodrigo, Burks, Jared K., DiNardo, Courtney, Daver, Naval, Jabbour, Elias, Wang, Jing, Kantarjian, Hagop M., Andreeff, Michael, Grant, Steven, Leverson, Joel D., Sampath, Deepak, Konopleva, Marina
Format: Artigo
Sprache:Inglês
Veröffentlicht: Ferrata Storti Foundation 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049339/
https://ncbi.nlm.nih.gov/pubmed/31123034
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2018.205534
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