Human BCR/ABL1 induces chronic myeloid leukemia-like disease in zebrafish

Chronic myeloid leukemia (CML) is induced by the BCR/ABL1 oncogene, which encodes a protein tyrosine kinase. We examined the effect of direct overexpression of the human p210(BCR/ABL1) oncoprotein in zebrafish. Humanized p210(BCR/ABL1) protein was detectable in Tg(hsp70: p210(BCR/ABL1)) transgenic z...

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Pubblicato in:Haematologica
Autori principali: Xu, Mengchang, Ye, Yin, Ye, Zhi’an, Xu, Song’en, Liu, Wei, Xu, Jin, Zhang, Yiyue, Liu, Qifa, Huang, Zhibin, Zhang, Wenqing
Natura: Artigo
Lingua:Inglês
Pubblicazione: Ferrata Storti Foundation 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049331/
https://ncbi.nlm.nih.gov/pubmed/31289206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3324/haematol.2019.215939
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