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Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling
The COP9 signalosome (CSN) is an evolutionarily conserved eight-subunit (CSN1–8) protein complex that controls protein ubiquitination by deneddylating Cullin-RING E3 ligases (CRLs). The activation and function of CSN hinges on its structural dynamics, which has been challenging to decipher by conven...
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| Pubblicato in: | Proc Natl Acad Sci U S A |
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| Autori principali: | , , , , , , , , , |
| Natura: | Artigo |
| Lingua: | Inglês |
| Pubblicazione: |
National Academy of Sciences
2020
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| Soggetti: | |
| Accesso online: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7049115/ https://ncbi.nlm.nih.gov/pubmed/32034103 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915542117 |
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