Structural dynamics of the human COP9 signalosome revealed by cross-linking mass spectrometry and integrative modeling

The COP9 signalosome (CSN) is an evolutionarily conserved eight-subunit (CSN1–8) protein complex that controls protein ubiquitination by deneddylating Cullin-RING E3 ligases (CRLs). The activation and function of CSN hinges on its structural dynamics, which has been challenging to decipher by conven...

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Publicado en:Proc Natl Acad Sci U S A
Autores principales: Gutierrez, Craig, Chemmama, Ilan E., Mao, Haibin, Yu, Clinton, Echeverria, Ignacia, Block, Sarah A., Rychnovsky, Scott D., Zheng, Ning, Sali, Andrej, Huang, Lan
Formato: Artigo
Lenguaje:Inglês
Publicado: National Academy of Sciences 2020
Materias:
Biological Sciences
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC7049115/
https://ncbi.nlm.nih.gov/pubmed/32034103
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1915542117
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