p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Squamous cell carcinoma (SCC), a malignancy arising across multiple anatomical sites, is responsible for significant cancer mortality due to insufficient therapeutic options. Here, we identify exceptional glucose reliance among SCCs dictated by hyperactive GLUT1-mediated glucose influx. Mechanistica...

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Udgivet i:Cell Rep
Main Authors: Hsieh, Meng-Hsiung, Choe, Joshua H., Gadhvi, Jashkaran, Kim, Yoon Jung, Arguez, Marcus A., Palmer, Madison, Gerold, Haleigh, Nowak, Chance, Do, Hung, Mazambani, Simbarashe, Knighton, Jordan K., Cha, Matthew, Goodwin, Justin, Kang, Min Kyu, Jeong, Ji Yun, Lee, Shin Yup, Faubert, Brandon, Xuan, Zhenyu, Abel, E. Dale, Scafoglio, Claudio, Shackelford, David B., Minna, John D., Singh, Pankaj K., Shulaev, Vladimir, Bleris, Leonidas, Hoyt, Kenneth, Kim, James, Inoue, Masahiro, DeBerardinis, Ralph J., Kim, Tae Hoon, Kim, Jung-whan
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048935/
https://ncbi.nlm.nih.gov/pubmed/31412252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.027
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