p63 and SOX2 Dictate Glucose Reliance and Metabolic Vulnerabilities in Squamous Cell Carcinomas

Squamous cell carcinoma (SCC), a malignancy arising across multiple anatomical sites, is responsible for significant cancer mortality due to insufficient therapeutic options. Here, we identify exceptional glucose reliance among SCCs dictated by hyperactive GLUT1-mediated glucose influx. Mechanistica...

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Vydáno v:Cell Rep
Hlavní autoři: Hsieh, Meng-Hsiung, Choe, Joshua H., Gadhvi, Jashkaran, Kim, Yoon Jung, Arguez, Marcus A., Palmer, Madison, Gerold, Haleigh, Nowak, Chance, Do, Hung, Mazambani, Simbarashe, Knighton, Jordan K., Cha, Matthew, Goodwin, Justin, Kang, Min Kyu, Jeong, Ji Yun, Lee, Shin Yup, Faubert, Brandon, Xuan, Zhenyu, Abel, E. Dale, Scafoglio, Claudio, Shackelford, David B., Minna, John D., Singh, Pankaj K., Shulaev, Vladimir, Bleris, Leonidas, Hoyt, Kenneth, Kim, James, Inoue, Masahiro, DeBerardinis, Ralph J., Kim, Tae Hoon, Kim, Jung-whan
Médium: Artigo
Jazyk:Inglês
Vydáno: 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048935/
https://ncbi.nlm.nih.gov/pubmed/31412252
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.07.027
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