Stromal Hedgehog pathway activation by IHH suppresses lung adenocarcinoma growth and metastasis by limiting reactive oxygen species

Activation of the Hedgehog (Hh) signaling pathway by mutations within its components drives the growth of several cancers. However, the role of Hh pathway activation in lung cancers has been controversial. Here, we demonstrate that the canonical Hh signaling pathway is activated in lung stroma by Hh...

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I publikationen:Oncogene
Huvudupphovsmän: Kasiri, Sahba, Chen, Baozhi, Wilson, Alexandra N., Reczek, Annika, Mazambani, Simbarashe, Gadhvi, Jashkaran, Noel, Evan, Marriam, Ummay, Mino, Barbara, Lu, Wei, Girard, Luc, Solis, Luisa M., Luby-Phelps, Katherine, Bishop, Justin, Kim, Jung-Whan, Kim, James
Materialtyp: Artigo
Språk:Inglês
Publicerad: Nature Publishing Group UK 2020
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Article
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7160060/
https://ncbi.nlm.nih.gov/pubmed/32108165
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-020-1224-5
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