Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency

Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood. Here, we report the existence of two types of enhancer units within SEs...

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Veröffentlicht in:Nat Commun
Hauptverfasser: Bell, Emma, Curry, Edward W., Megchelenbrink, Wout, Jouneau, Luc, Brochard, Vincent, Tomaz, Rute A., Mau, King Hang T., Atlasi, Yaser, de Souza, Roshni A., Marks, Hendrik, Stunnenberg, Hendrik G., Jouneau, Alice, Azuara, Véronique
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2020
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Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048827/
https://ncbi.nlm.nih.gov/pubmed/32111830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14916-7
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