Dynamic CpG methylation delineates subregions within super-enhancers selectively decommissioned at the exit from naive pluripotency

Clusters of enhancers, referred as to super-enhancers (SEs), control the expression of cell identity genes. The organisation of these clusters, and how they are remodelled upon developmental transitions remain poorly understood. Here, we report the existence of two types of enhancer units within SEs...

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Detalhes bibliográficos
Publicado no:Nat Commun
Main Authors: Bell, Emma, Curry, Edward W., Megchelenbrink, Wout, Jouneau, Luc, Brochard, Vincent, Tomaz, Rute A., Mau, King Hang T., Atlasi, Yaser, de Souza, Roshni A., Marks, Hendrik, Stunnenberg, Hendrik G., Jouneau, Alice, Azuara, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048827/
https://ncbi.nlm.nih.gov/pubmed/32111830
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14916-7
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