Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells

Th17 cells are critical drivers of autoimmune diseases and immunopathology. There is an unmet need to develop therapies targeting pathogenic Th17 cells for the treatment of autoimmune disorders. Here, we report that anxiolytic FGIN-1-27 inhibits differentiation and pathogenicity of Th17 cells in vit...

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Publicado no:Sci Rep
Main Authors: Singh, Anju, Dashnyam, Myagmarjav, Chim, Bryan, Escobar, Thelma M., Dulcey, Andrés E., Hu, Xin, Wilson, Kelli M., Koganti, Prasanthi P., Spinner, Camille A., Xu, Xin, Jadhav, Ajit, Southall, Noel, Marugan, Juan, Selvaraj, Vimal, Lazarevic, Vanja, Muljo, Stefan A., Ferrer, Marc
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2020
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048748/
https://ncbi.nlm.nih.gov/pubmed/32111885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60610-5
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