Anxiolytic Drug FGIN-1-27 Ameliorates Autoimmunity by Metabolic Reprogramming of Pathogenic Th17 Cells

Th17 cells are critical drivers of autoimmune diseases and immunopathology. There is an unmet need to develop therapies targeting pathogenic Th17 cells for the treatment of autoimmune disorders. Here, we report that anxiolytic FGIN-1-27 inhibits differentiation and pathogenicity of Th17 cells in vit...

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Bibliografiset tiedot
Julkaisussa:Sci Rep
Päätekijät: Singh, Anju, Dashnyam, Myagmarjav, Chim, Bryan, Escobar, Thelma M., Dulcey, Andrés E., Hu, Xin, Wilson, Kelli M., Koganti, Prasanthi P., Spinner, Camille A., Xu, Xin, Jadhav, Ajit, Southall, Noel, Marugan, Juan, Selvaraj, Vimal, Lazarevic, Vanja, Muljo, Stefan A., Ferrer, Marc
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: Nature Publishing Group UK 2020
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Article
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048748/
https://ncbi.nlm.nih.gov/pubmed/32111885
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60610-5
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