Nrf2 Suppresses Oxidative Stress and Inflammation in App Knock-In Alzheimer’s Disease Model Mice

Nrf2 (NF-E2-related-factor 2) is a stress-responsive transcription factor that protects cells against oxidative stresses. To clarify whether Nrf2 prevents Alzheimer’s disease (AD), AD model App(NL-G-F/NL-G-F) knock-in (App(NLGF)) mice were studied in combination with genetic Nrf2 induction model Kea...

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Détails bibliographiques
Publié dans:Mol Cell Biol
Auteurs principaux: Uruno, Akira, Matsumaru, Daisuke, Ryoke, Rie, Saito, Ritsumi, Kadoguchi, Shiori, Saigusa, Daisuke, Saito, Takashi, Saido, Takaomi C., Kawashima, Ryuta, Yamamoto, Masayuki
Format: Artigo
Langue:Inglês
Publié: American Society for Microbiology 2020
Sujets:
Research Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC7048263/
https://ncbi.nlm.nih.gov/pubmed/31932477
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.00467-19
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