The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS

RATIONALE: The role of PI (protease inhibitor) type Z heterozygotes and additional rare variant genotypes in the gene encoding alpha-1 antitrypsin, SERPINA1 (serpin peptidase inhibitor, clade A, member 1), in determining chronic obstructive pulmonary disease risk and severity is controversial. OBJEC...

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Bibliografiske detaljer
Udgivet i:Am J Respir Crit Care Med
Main Authors: Ortega, Victor E., Li, Xingnan, O’Neal, Wanda K., Lackey, Lela, Ampleford, Elizabeth, Hawkins, Gregory A., Grayeski, Philip J., Laederach, Alain, Barjaktarevic, Igor, Barr, R. Graham, Cooper, Christopher, Couper, David, Han, MeiLan K., Kanner, Richard E., Kleerup, Eric C., Martinez, Fernando J., Paine, Robert, Peters, Stephen P., Pirozzi, Cheryl, Rennard, Stephen I., Woodruff, Prescott G., Hoffman, Eric A., Meyers, Deborah A., Bleecker, Eugene R.
Format: Artigo
Sprog:Inglês
Udgivet: American Thoracic Society 2019
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Original Articles
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047460/
https://ncbi.nlm.nih.gov/pubmed/31661293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201904-0769OC
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