The Effects of Rare SERPINA1 Variants on Lung Function and Emphysema in SPIROMICS

RATIONALE: The role of PI (protease inhibitor) type Z heterozygotes and additional rare variant genotypes in the gene encoding alpha-1 antitrypsin, SERPINA1 (serpin peptidase inhibitor, clade A, member 1), in determining chronic obstructive pulmonary disease risk and severity is controversial. OBJEC...

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Vydáno v:Am J Respir Crit Care Med
Hlavní autoři: Ortega, Victor E., Li, Xingnan, O’Neal, Wanda K., Lackey, Lela, Ampleford, Elizabeth, Hawkins, Gregory A., Grayeski, Philip J., Laederach, Alain, Barjaktarevic, Igor, Barr, R. Graham, Cooper, Christopher, Couper, David, Han, MeiLan K., Kanner, Richard E., Kleerup, Eric C., Martinez, Fernando J., Paine, Robert, Peters, Stephen P., Pirozzi, Cheryl, Rennard, Stephen I., Woodruff, Prescott G., Hoffman, Eric A., Meyers, Deborah A., Bleecker, Eugene R.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Thoracic Society 2019
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Original Articles
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047460/
https://ncbi.nlm.nih.gov/pubmed/31661293
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1164/rccm.201904-0769OC
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