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Competitive Metabolite Profiling of Natural Products Reveals Subunit Specific Inhibitors of the 20S Proteasome
[Image: see text] We have developed a syringolin-based chemical probe and explored its utility for the profiling of metabolite extracts as potent inhibitors of the 20S proteasome. Activity-guided fractionation by competitive labeling allowed us to isolate and identify glidobactin A and C as well as...
Shranjeno v:
| izdano v: | ACS Cent Sci |
|---|---|
| Main Authors: | , , , , , |
| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
American Chemical Society
2020
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| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC7047272/ https://ncbi.nlm.nih.gov/pubmed/32123742 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b01170 |
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