A Novel G Protein-Biased and Subtype-Selective Agonist for a G Protein-Coupled Receptor Discovered from Screening Herbal Extracts

[Image: see text] Subtype selectivity and functional bias are vital in current drug discovery for G protein-coupled receptors (GPCRs) as selective and biased ligands are expected to yield drug leads with optimal on-target benefits and minimal side-effects. However, structure-based design and medicin...

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Publicado no:ACS Cent Sci
Main Authors: Zhang, Bingjie, Zhao, Simeng, Yang, Dehua, Wu, Yiran, Xin, Ye, Cao, Haijie, Huang, Xi-Ping, Cai, Xiaoqing, Sun, Wen, Ye, Na, Xu, Yueming, Peng, Yao, Zhao, Suwen, Liu, Zhi-Jie, Zhong, Guisheng, Wang, Ming-Wei, Shui, Wenqing
Formato: Artigo
Idioma:Inglês
Publicado em: American Chemical Society 2020
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047268/
https://ncbi.nlm.nih.gov/pubmed/32123739
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/acscentsci.9b01125
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