Ascorbic Acid Sensitizes Colorectal Carcinoma to the Cytotoxicity of Arsenic Trioxide via Promoting Reactive Oxygen Species-Dependent Apoptosis and Pyroptosis

Arsenic trioxide (ATO) is an effective therapeutic agent against acute promyelocytic leukemia (APL); however, its anti-tumor effect on solid tumors such as colorectal cancer (CRC) is still in debate. Ascorbic acid (AA) also produces a selective cytotoxic activity against tumor cells. Here, we exploi...

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Publicat a:Front Pharmacol
Autors principals: Tian, Wei, Wang, Zhuo, Tang, Nan-nan, Li, Jia-tong, Liu, Yu, Chu, Wen-Feng, Yang, Bao-Feng
Format: Artigo
Idioma:Inglês
Publicat: Frontiers Media S.A. 2020
Matèries:
Pharmacology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047232/
https://ncbi.nlm.nih.gov/pubmed/32153415
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2020.00123
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