Generation of Novel Genetic Models to Dissect Resistance to Thyroid Hormone Receptor α in Zebrafish

Background: Patients with mutations of the thyroid hormone receptor alpha (THRA) gene show resistance to thyroid hormone alpha (RTHα). No amendable mouse models are currently available to elucidate deleterious effects of TRα1 mutants during early development. Zebrafish with transient suppressed expr...

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Vydáno v:Thyroid
Hlavní autoři: Han, Cho Rong, Holmsen, Erik, Carrington, Blake, Bishop, Kevin, Zhu, Yuelin Jack, Starost, Matthew, Meltzer, Paul, Sood, Raman, Liu, Paul, Cheng, Sheue-yann
Médium: Artigo
Jazyk:Inglês
Vydáno: Mary Ann Liebert, Inc., publishers 2020
Témata:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047097/
https://ncbi.nlm.nih.gov/pubmed/31952464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2019.0598
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