Generation of Novel Genetic Models to Dissect Resistance to Thyroid Hormone Receptor α in Zebrafish

Background: Patients with mutations of the thyroid hormone receptor alpha (THRA) gene show resistance to thyroid hormone alpha (RTHα). No amendable mouse models are currently available to elucidate deleterious effects of TRα1 mutants during early development. Zebrafish with transient suppressed expr...

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Bibliographische Detailangaben
Veröffentlicht in:Thyroid
Hauptverfasser: Han, Cho Rong, Holmsen, Erik, Carrington, Blake, Bishop, Kevin, Zhu, Yuelin Jack, Starost, Matthew, Meltzer, Paul, Sood, Raman, Liu, Paul, Cheng, Sheue-yann
Format: Artigo
Sprache:Inglês
Veröffentlicht: Mary Ann Liebert, Inc., publishers 2020
Schlagworte:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047097/
https://ncbi.nlm.nih.gov/pubmed/31952464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2019.0598
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