Generation of Novel Genetic Models to Dissect Resistance to Thyroid Hormone Receptor α in Zebrafish

Background: Patients with mutations of the thyroid hormone receptor alpha (THRA) gene show resistance to thyroid hormone alpha (RTHα). No amendable mouse models are currently available to elucidate deleterious effects of TRα1 mutants during early development. Zebrafish with transient suppressed expr...

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Detalhes bibliográficos
Publicado no:Thyroid
Main Authors: Han, Cho Rong, Holmsen, Erik, Carrington, Blake, Bishop, Kevin, Zhu, Yuelin Jack, Starost, Matthew, Meltzer, Paul, Sood, Raman, Liu, Paul, Cheng, Sheue-yann
Formato: Artigo
Idioma:Inglês
Publicado em: Mary Ann Liebert, Inc., publishers 2020
Assuntos:
Thyroid Economy: Regulation, Cell Biology, and Thyroid Hormone Metabolism and Action
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7047097/
https://ncbi.nlm.nih.gov/pubmed/31952464
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/thy.2019.0598
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