Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation

Parkinson’s Disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, the extracellular accumulation of toxic α-synuclein (αSYN) aggregates, and neuroinflammation. Microglia, resident macrophages of the brain, are one of the critical cell types involved in n...

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Detalhes bibliográficos
Publicado no:Front Bioeng Biotechnol
Principais autores: Zhao, Nanxia, Yang, Xue, Calvelli, Hannah R., Cao, Yue, Francis, Nicola L., Chmielowski, Rebecca A., Joseph, Laurie B., Pang, Zhiping P., Uhrich, Kathryn E., Baum, Jean, Moghe, Prabhas V.
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2020
Assuntos:
Bioengineering and Biotechnology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046761/
https://ncbi.nlm.nih.gov/pubmed/32154238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.00112
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