Antioxidant Nanoparticles for Concerted Inhibition of α-Synuclein Fibrillization, and Attenuation of Microglial Intracellular Aggregation and Activation

Parkinson’s Disease is characterized by the loss of dopaminergic neurons in the substantia nigra pars compacta, the extracellular accumulation of toxic α-synuclein (αSYN) aggregates, and neuroinflammation. Microglia, resident macrophages of the brain, are one of the critical cell types involved in n...

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Bibliografiska uppgifter
I publikationen:Front Bioeng Biotechnol
Huvudupphovsmän: Zhao, Nanxia, Yang, Xue, Calvelli, Hannah R., Cao, Yue, Francis, Nicola L., Chmielowski, Rebecca A., Joseph, Laurie B., Pang, Zhiping P., Uhrich, Kathryn E., Baum, Jean, Moghe, Prabhas V.
Materialtyp: Artigo
Språk:Inglês
Publicerad: Frontiers Media S.A. 2020
Ämnen:
Bioengineering and Biotechnology
Länkar:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046761/
https://ncbi.nlm.nih.gov/pubmed/32154238
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fbioe.2020.00112
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