Polymer Brain-Nanotherapeutics for Multipronged Inhibition of Microglial α-Synuclein Aggregation, Activation, and Neurotoxicity

Neuroinflammation, a common neuropathologic feature of neurodegenerative disorders including Parkinson disease (PD), is frequently exacerbated by microglial activation. The extracellular protein α-synuclein (ASYN), whose aggregation is characteristic of PD, remains a key therapeutic target, but the...

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Detalhes bibliográficos
Publicado no:Biomaterials
Main Authors: Bennett, Neal K., Chmielowski, Rebecca, Abdelhamid, Dalia S., Faig, Jonathan J., Francis, Nicola, Baum, Jean, Pang, Zhiping P., Uhrich, Kathryn E., Moghe, Prabhas V.
Formato: Artigo
Idioma:Inglês
Publicado em: 2016
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC5262519/
https://ncbi.nlm.nih.gov/pubmed/27736702
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.biomaterials.2016.10.001
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