Cerebellum-enriched protein INPP5A contributes to selective neuropathology in mouse model of spinocerebellar ataxias type 17

Spinocerebellar ataxias 17 (SCA17) is caused by polyglutamine (polyQ) expansion in the TATA box-binding protein (TBP). The selective neurodegeneration in the cerebellum in SCA17 raises the question of why ubiquitously expressed polyQ proteins can cause neurodegeneration in distinct brain regions in...

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Pubblicato in:Nat Commun
Autori principali: Liu, Qiong, Huang, Shanshan, Yin, Peng, Yang, Su, Zhang, Jennifer, Jing, Liang, Cheng, Siying, Tang, Beisha, Li, Xiao-Jiang, Pan, Yongcheng, Li, Shihua
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2020
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046734/
https://ncbi.nlm.nih.gov/pubmed/32107387
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-14931-8
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