Structural and dynamic insights revealing how lipase binding domain MD1 of Pseudomonas aeruginosa foldase affects lipase activation

Folding and cellular localization of many proteins of Gram-negative bacteria rely on a network of chaperones and secretion systems. Among them is the lipase-specific foldase Lif, a membrane-bound steric chaperone that tightly binds (K(D) = 29 nM) and mediates folding of the lipase LipA, a virulence...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Viegas, Aldino, Dollinger, Peter, Verma, Neha, Kubiak, Jakub, Viennet, Thibault, Seidel, Claus A. M., Gohlke, Holger, Etzkorn, Manuel, Kovacic, Filip, Jaeger, Karl-Erich
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2020
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046727/
https://ncbi.nlm.nih.gov/pubmed/32107397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-020-60093-4
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