Blockade of JAK2 protects mice against hypoxia‐induced pulmonary arterial hypertension by repressing pulmonary arterial smooth muscle cell proliferation

OBJECTIVES: Hypoxia is an important risk factor for pulmonary arterial remodelling in pulmonary arterial hypertension (PAH), and the Janus kinase 2 (JAK2) is believed to be involved in this process. In the present report, we aimed to investigate the role of JAK2 in vascular smooth muscle cells durin...

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Veröffentlicht in:Cell Prolif
Hauptverfasser: Zhang, Lei, Wang, Yi, Wu, Guorao, Rao, Lizong, Wei, Yanqiu, Yue, Huihui, Yuan, Ting, Yang, Ping, Xiong, Fei, Zhang, Shu, Zhou, Qing, Chen, Zhishui, Li, Jinxiu, Mo, Bi‐Wen, Zhang, Huilan, Xiong, Weining, Wang, Cong‐Yi
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2020
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Original Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7046303/
https://ncbi.nlm.nih.gov/pubmed/31943454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/cpr.12742
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