Knockdown of Long Noncoding RNAs Hepatocyte Nuclear Factor 1α Antisense RNA 1 and Hepatocyte Nuclear Factor 4α Antisense RNA 1 Alters Susceptibility of Acetaminophen-Induced Cytotoxicity in HepaRG Cells

Acetaminophen (APAP) is a commonly used over-the-counter drug for its analgesic and antipyretic effects. However, APAP overdose leads to severe APAP-induced liver injury (AILI) and even death as a result of the accumulation of N-acetyl-p-benzoquinone imine, the toxic metabolite of APAP generated by...

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Bibliografische gegevens
Gepubliceerd in:Mol Pharmacol
Hoofdauteurs: Chen, Liming, Wang, Pei, Manautou, José E., Zhong, Xiao-bo
Formaat: Artigo
Taal:Inglês
Gepubliceerd in: The American Society for Pharmacology and Experimental Therapeutics 2020
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Articles
Online toegang:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045890/
https://ncbi.nlm.nih.gov/pubmed/32029527
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/mol.119.118778
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