Allosteric inhibition of CRISPR-Cas9 by bacteriophage-derived peptides

BACKGROUND: CRISPR-Cas9 has been developed as a therapeutic agent for various infectious and genetic diseases. In many clinically relevant applications, constitutively active CRISPR-Cas9 is delivered into human cells without a temporal control system. Excessive and prolonged expression of CRISPR-Cas...

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Detalhes bibliográficos
Publicado no:Genome Biol
Main Authors: Cui, Yan-ru, Wang, Shao-jie, Chen, Jun, Li, Jie, Chen, Wenzhang, Wang, Shuyue, Meng, Bing, Zhu, Wei, Zhang, Zhuhong, Yang, Bei, Jiang, Biao, Yang, Guang, Ma, Peixiang, Liu, Jia
Formato: Artigo
Idioma:Inglês
Publicado em: BioMed Central 2020
Assuntos:
Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045643/
https://ncbi.nlm.nih.gov/pubmed/32102684
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13059-020-01956-x
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