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Gastrointestinal motility, dysbiosis and opioid-induced tolerance: is there a link?

Studies show that gut microbial dysbiosis induced by chronic opioid use is linked to central opioid tolerance. Here, we suggest that a persistent decrease in gastrointestinal motility by opioids is a primary cause of gut microbial dysbiosis and that improving gastrointestinal transit might be a stra...

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Detalhes bibliográficos
Publicado no:Nat Rev Gastroenterol Hepatol
Main Authors: Akbarali, Hamid I., Dewey, William L.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7045338/
https://ncbi.nlm.nih.gov/pubmed/31024090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41575-019-0150-x
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