Microglia Actively Remodel Adult Hippocampal Neurogenesis through the Phagocytosis Secretome

During adult hippocampal neurogenesis, most newborn cells undergo apoptosis and are rapidly phagocytosed by resident microglia to prevent the spillover of intracellular contents. Here, we propose that phagocytosis is not merely passive corpse removal but has an active role in maintaining neurogenesi...

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Publicat a:J Neurosci
Autors principals: Diaz-Aparicio, Irune, Paris, Iñaki, Sierra-Torre, Virginia, Plaza-Zabala, Ainhoa, Rodríguez-Iglesias, Noelia, Márquez-Ropero, Mar, Beccari, Sol, Huguet, Paloma, Abiega, Oihane, Alberdi, Elena, Matute, Carlos, Bernales, Irantzu, Schulz, Angela, Otrokocsi, Lilla, Sperlagh, Beata, Happonen, Kaisa E., Lemke, Greg, Maletic-Savatic, Mirjana, Valero, Jorge, Sierra, Amanda
Format: Artigo
Idioma:Inglês
Publicat: Society for Neuroscience 2020
Matèries:
Research Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044727/
https://ncbi.nlm.nih.gov/pubmed/31896673
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.0993-19.2019
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