Initiation of human mammary cell tumorigenesis by mutant KRAS requires YAP inactivation

High YAP activity is associated with poor prognosis human breast cancers, but its role during the initial stage of mammary cell transformation is unknown. To address this question, we designed experiments that exploit the ability of KRAS(G12D)-transduced subsets of freshly isolated normal human mamm...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Oncogene
Egile Nagusiak: Lefort, Sylvain, Tan, Susanna, Balani, Sneha, Rafn, Bo, Pellacani, Davide, Hirst, Martin, Sorensen, Poul H., Eaves, Connie J.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Nature Publishing Group UK 2019
Gaiak:
Article
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044112/
https://ncbi.nlm.nih.gov/pubmed/31772328
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-019-1111-0
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