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Stimulating pyruvate dehydrogenase complex reduces itaconate levels and enhances TCA cycle anabolic bioenergetics in acutely inflamed monocytes

The pyruvate dehydrogenase complex (PDC)/pyruvate dehydrogenase kinase (PDK) axis directs the universal survival principles of immune resistance and tolerance in monocytes by controlling anabolic and catabolic energetics. Immune resistance shifts to immune tolerance during inflammatory shock syndrom...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Leukoc Biol
Prif Awduron: Zhu, Xuewei, Long, David, Zabalawi, Manal, Ingram, Brian, Yoza, Barbara K., Stacpoole, Peter W., McCall, Charles E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: 2020
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7044062/
https://ncbi.nlm.nih.gov/pubmed/31894617
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/JLB.3A1119-236R
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