Pyruvate dehydrogenase complex stimulation promotes immunometabolic homeostasis and sepsis survival

Limited understanding of the mechanisms responsible for life-threatening organ and immune failure hampers scientists’ ability to design sepsis treatments. Pyruvate dehydrogenase kinase 1 (PDK1) is persistently expressed in immune-tolerant monocytes of septic mice and humans and deactivates mitochond...

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Veröffentlicht in:JCI Insight
Hauptverfasser: McCall, Charles E., Zabalawi, Manal, Liu, Tiefu, Martin, Ayana, Long, David L., Buechler, Nancy L., Arts, Rob J. W., Netea, Mihai, Yoza, Barbara K., Stacpoole, Peter W., Vachharajani, Vidula
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Clinical Investigation 2018
Schlagworte:
Research Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6129136/
https://ncbi.nlm.nih.gov/pubmed/30089711
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1172/jci.insight.99292
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