Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice

OBJECTIVE: Obesity increases morbidity and resource utilization in sepsis patients. Sepsis transitions from early/hyper-inflammatory to late/hypo-inflammatory phase. Majority of sepsis-mortality occurs during the late sepsis; no therapies exist to treat late sepsis. In lean mice, we have shown that...

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Udgivet i:PLoS One
Main Authors: Wang, Xianfeng, Buechler, Nancy L., Martin, Ayana, Wells, Jonathan, Yoza, Barbara, McCall, Charles E., Vachharajani, Vidula
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2016
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC4976857/
https://ncbi.nlm.nih.gov/pubmed/27500833
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0160431
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