HIV protease cleaves the antiviral m(6)A reader protein YTHDF3 in the viral particle

N(6)-methyladenosine (m(6)A) is the most abundant HIV RNA modification but the interplay between the m(6)A reader protein YTHDF3 and HIV replication is not well understood. We found that knockout of YTHDF3 in human CD4+ T-cells increases infection supporting the role of YTHDF3 as a restriction facto...

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Detalhes bibliográficos
Publicado no:PLoS Pathog
Main Authors: Jurczyszak, Denise, Zhang, Wen, Terry, Sandra N., Kehrer, Thomas, Bermúdez González, Maria C., McGregor, Emma, Mulder, Lubbertus C. F., Eckwahl, Matthew J., Pan, Tao, Simon, Viviana
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2020
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Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC7043784/
https://ncbi.nlm.nih.gov/pubmed/32053707
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008305
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